Tetrahydrothiopyranopyrimidine derivatives as anti-HIV agent

A compound of tetrahydrothiopyranopyrimidine, or pharmaceutically acceptable salt thereof, the compound having a general formula I or II shown as following:

• wherein
• A is S(═O)n or CH2;
• B is S(═O)n or CH2, while either A or B is S(═O)n in the compound;
• n=0, 1 or 2;
• X is O or NH;
• R1, R2 and R3 are independently selected from a group consisting of H, halo, CN, CF3, NH2, OH, C1-6alkyl, C1-6alkyloxy, C2-6alkenyl, trifluoromethyl, amino, hydroxy, cyanovinyl, cyanoethyl and cyclopropyl;
• Ar is selected from a group consisting of an optionally substituted benzyl ring, an optionally substituted benzene ring, an optionally substituted naphthalene ring, a substituted 6-membered heterocyclic ring, a substituted 5-membered heterocyclic ring, a substituted 6-membered and 5-membered heterocyclic ring, a substituted 6- and 6-membered heterocyclic ring, a substituted five-membered and five-membered heterocyclic ring, a substituted benzo five-membered heterocyclic ring and a substituted benzo-six-membered heterocyclic ring.