Tetrahydropyrimidodiazepine and dihydropyridodiazepine compounds for treating pain and pain related conditions

A compound of general formula (I):

• wherein:
• X is CRx or N;
• Rx is a hydrogen atom;
• a branched or unbranched C1-6 alkyl radical;
• or a halogen atom;
• Y is CH2 or C═O;
• m is 0, 1 or 2;
• R1 is a hydrogen atom;
• or a linear or branched C1-6 alkyl radical;
• R2 is a hydrogen atom;
• a branched or unbranched C1-6 alkyl radical;
• a halogen atom;
• haloalkyl;
• —SR2a;
• —NR2aR2b;
• or —OR2a;
• R2a and R2b independently represent a hydrogen atom;
• a branched or unbranched C1-4 alkyl radical;
• a C3-6 cycloalkyl radical;
• —(CH2)r-aryl, wherein the aryl group is a 6-membered ring and r is 0, 1 or 2;
• —(CH2)s-heteroaryl, wherein the heteroaryl group is a 5 or 6-membered aromatic ring having at least one nitrogen atom and optionally having one or more additional heteroatoms selected from nitrogen, oxygen and sulfur, optionally substituted by at least one halogen atom and s is 0, 1 or 2;
• or —(CH2)2—O—CH3;
• R3 is a hydrogen atom;
• —CN;
• —OH;
• halogen;
• branched or unbranched C1-6 alkyl radical;
• —(CH2)p—O—R4, wherein p is 0, 1 or 2;
• —(CH2)q—NR5R6, wherein q is 0, 1, 2 or 3;
• —C(CH3)2—CH2—NR5R6;
• —C(═O)NR5R6;
• a 5 or 6 membered heteroaryl group having at least one heteroatom selected from N, O and S, and being substituted by one or two R7 substituents and which may be attached to the phenyl ring by a C1-3 alkylene group;
• a 5 or 6 membered heterocycloalkyl radical having one or two nitrogen atoms and being unsubstituted or optionally substituted by one or two R8 substituents and which may be attached to the phenyl ring by a C1-3 alkylene group;
• or —C(═O)OR9;
• R4 is a hydrogen atom;
• a branched or unbranched C1-6 alkyl radical;
• a tert-butyldimethylsilyl radical;
• a methylbenzenesulfonate radical;
• a —CHR4aR4b;
• a —CH2—CHR4aR4b;
• or a 5 or 6-membered heterocycloalkyl radical having at least one N atom and being optionally substituted by one or two R4c radical;
• R4a is a hydrogen atom;
• a branched or unbranched C1-6 alkyl radical;
• a 5 or 6-membered aryl group optionally substituted by a at least one halogen atom;
• or a 5 or 6-membered heteroaryl group, having at least one heteroatom selected from N, O or S, and being optionally substituted by at least a branched or unbranched C1-6 alkyl radical;
• R4b is a —(CH2)j—NR4b′R4b″, wherein j is 0, 1, 2 or 3;
• R4b′ and R4b″ independently represent a hydrogen atom;
• a branched or unbranched C1-6 alkyl radical;
• a C1-6 haloalkyl radical;
• a benzyl group;
• a phenethyl group;
• a tert-butyloxycarbonyl group;
• or a (trimethylsilyl)ethyloxycarbonyl group;
• or
• R4b′ and R4b″, together with the nitrogen to which they are attached, form a 5 or 6-membered heterocycloalkyl radical optionally containing an additional heteroatom selected from N, O and S;
• R4c is a hydrogen atom;
• a branched or unbranched C1-6 alkyl radical;
• a phenyl group;
• a benzyl group;
• or a tert-butyloxycarbonyl group;
• R5 and R6 independently represent a hydrogen atom;
• a branched or unbranched C1-6 alkyl radical;
• a tert-butyloxycarbonyl group;
• a benzyl group;
• a phenethyl group;
• or
• R5 and R6, together with the nitrogen to which they are attached, form a 5 or 6-membered heterocycloalkyl radical which may be mono or bisubstituted by a phenyl group, which may be optionally substituted by a branched or unbranched C1-6 alkyl radical, a halogen atom, —OH or —CN;
• or by an —NRR′, wherein R and R′ independently represent a hydrogen atom or a branched or unbranched C1-6 alkyl radical;
• or
• R5 and R6, together with the nitrogen atom to which they are attached, form 5 or 6-membered heterocycloalkyl radical which may be spirofused to another 5 or 6-membered heterocycloalkyl radical having at least one heteroatom selected from N, O and S, optionally containing an additional heteroatom selected from N, O and S, which may be substituted by one or more substituents selected from a branched or unbranched C1-6 alkyl radical;
• a halogen atom, an —OH, a —CN and an ═O;
• R7 is a hydrogen atom;
• a branched or unbranched C1-6 alkyl radical;
• a —C(═O)H group;
• a —(CH2)p—NR7aR7b, wherein p is 0, 1, 2 or 3;
• or a —(CH)R7cR7d;
• R7a and R7b independently represent a hydrogen atom;
• a branched or unbranched C1-6 alkyl radical;
• a tert-butyloxycarbonyl group;
• a benzyl group optionally substituted by a halogen;
• a phenethyl group;
• a —(CH2)-cyclopropyl;
• a hydroxyethoxyethyl group;
• an —OH;
• a —C(═O)H group;
• a pyridinylmethyl group;
• or
• R7a and R7b, together with the nitrogen to which they are attached, form a 5 or 6-membered heterocycloalkyl radical which may additionally contain a second N atom, which radical may be substituted by a —NR7a′R7b′, wherein R7a′ and R7b′ independently represent a hydrogen atom or a branched or unbranched C1-6 alkyl radical;
• or by a phenyl group, which may be optionally substituted by a branched or unbranched C1-6 alkyl radical, a halogen atom, an —OH or a —CN;
• or
• R7a and R7b, together with the nitrogen atom to which they are attached, form 5 or 6-membered heterocycloalkyl radical which may be fused to a 5 or 6 membered aromatic ring or may be spirofused to either a single 5 or 6-membered heterocycloalkyl ring having at least one heteroatom selected from N, O and S, optionally containing an additional heteroatom selected from N, O and S, which may be substituted by one or more substituents selected from a branched or unbranched C1-6 alkyl radical, a halogen atom, an —OH, a —CN or an ═O;
• or may be spirofused to a bicyclic ring system formed by a 5 or 6-membered heterocycloalkyl ring having at least one heteroatom selected from N, O and S, optionally containing an additional heteroatom selected from N, O and S, fused to 5 or 6-membered aromatic ring;
• R7c and R7d independently represent a hydrogen atom;
• a branched or unbranched C1-6 alkyl radical;
• or C1-6alkoxy radical;
• and
• R8 is a hydrogen atom;
• a branched or unbranched C1-6 alkyl radical;
• a tert-butyloxycarbonyl group;
• a phenyl group;
• a benzyl group;
• a phenethyl group;
• or a —NR8a′R8b′, wherein R8a′ and R8b′ represent a hydrogen atom or a branched or unbranched C1-6 alkyl radical;
• and
• R9 is a hydrogen atom;
• or a linear or branched C1-6 alkyl radical;
• or a pharmaceutically acceptable salt, stereoisomer, or solvate thereof.