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US 10,590,132 B2Granted
Selective estrogen receptor down-regulators
AssigneeAstraZeneca AB
InventorsJohannes Wilhelmus Maria Nissink, James Stewart Scott, Thomas Andrew Moss, Samantha Jayne Hughes, Bernard Christophe Barlaam, Bin Yang
Life of this patent
Estimating the term…
Abstract
The specification relates to compounds of Formula (I): and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of cell proliferative disorders.
Claims12
A compound of Formula (IH):
- wherein:
- E is CH or N;
- Q is O, NH or NMe;
- R1 is CH2F or CHF2;
- R3 is H or Me;
- R4 is C1-3 alkyl, CHF2 or CF3;
- R7 is H, Me or F;
- R8 is H, Me or F;
- or
- R7 and R8 taken together with the carbon atom to which they are attached form a cyclobutyl ring;
- R11 is H, F, Cl, or OMe;
- R12 is H, F, Cl, CHF2, or Me;
- R15 is H or F;
- and
- R20 is H or Me;
- or a pharmaceutically acceptable salt thereof.
13 more elements
Dependencies are inferred from the claim text.