3,5-disubstituted-3H-imidazo[4,5-B]pyridine and 3,5-disubstituted-3H-[1,2,3]triazolo[4,5-B] pyridine compounds as modulators of protein kinases

A method of inhibiting the proliferative activity of a cell comprising contacting the cell with a compound of formula (IA-1):

• or a tautomer, stereoisomer, enantiomer, diastereomer, salt, or N-oxide thereof, wherein
• X is N;
• Cy2 is selected from substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclic group, substituted aryl, and substituted or unsubstituted heteroaryl;
• D is phenyl substituted with one to five substituents selected from halogen, substituted or unsubstituted alkyl and —CONRxRy;
• each occurrence of Rx and Ry is independently selected from hydrogen, hydroxy, halogen, carboxyl, cyano, nitro, oxo (═O), thio (═S), substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenylalkyl, substituted or unsubstituted heterocycyl, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroarylalkyl, —COORz, —C(O)Rz, —C(S)Rz, —C(O)NRzRz, —C(O)ONRzRz, —NRzRz, —NRzCONRzRz, —N(Rz)SORz, —N(Rz)SO2Rz, —(═N—N(Rz)Rz), —NRzC(O)ORz, —NRzC(O)Rz—, NRzC(S)Rz—NRzC(S)NRzRz, —SONRzRz—, —SO2NRzRz—, —ORz, —ORzC(O)NRzRz, —ORzC(O)ORz—, —OC(O)Rz, —OC(O)NRzRz, —RzNRzC(O)Rz, —RzORz, —RzC(O)ORz, —RzC(O)NRzRz, —RzC(O)Rz, RzOC(O)Rz, —SRz, —SORz, —SO2Rz, and —ONO2, or any two of Rx and Ry which are directly bound to a common atom may be joined to form (i) a substituted or unsubstituted, saturated or unsaturated 3-14 membered ring, which may optionally include one or more heteroatoms which may be the same or different and are selected from O, NRz or S, or (ii) an oxo (═O), thio (═S) or imino (═NRz);
• each occurrence of Rz is independently selected from hydrogen, hydroxy, halogen, carboxyl, cyano, nitro, oxo (═O), thio (═S), substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenylalkyl, substituted or unsubstituted heterocycyl, substituted or unsubstituted heterocyclcyalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroarylalkyl, and —ONO2, or any two of Rz which are directly bound to a common atom may be joined to form (i) a substituted or unsubstituted, saturated or unsaturated 3-14 membered ring, which may optionally include one or more heteroatoms which may be the same or different and are selected from O, NR′ (where R′ is H or alkyl) or S, or (ii) an oxo (═O), thio (═S) or imino (═NRz);
• R2 is hydrogen;
• L2 is —(CRaRb)n—;
• each occurrence of Ra and Rb may be the same or different and are independently selected from hydrogen and methyl;
• and
• n is 1.