Tetrahydroquinazoline derivatives useful as anticancer agents

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof;
• wherein:
• J is a heterocycle having 3-12 ring atoms, where J is optionally substituted with 1, 2, 3, 4, 5 or 6 R2;
• K is C6-C12 aryl, or K is heteroaryl having 5-12 ring atoms, where K is optionally substituted with 1, 2, 3, 4, 5, 6 or 7 R3;
• W is selected from the group consisting of:
• where W is optionally substituted with 1, 2 or 3 R5;
• each R1 is independently selected from the group consisting of C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyl-hydroxy, C1-C6 alkoxy, C1-C6 alkyl-C1-C6alkoxy, hydroxy, C2-C6 alkenyl, C2-C6 alkynyl, halogen, C1-C6 haloalkyl, cyano and —N(R6)2, or two R1 optionally join to form a heterocycle having 3-12 ring atoms or a C3-C6 cycloalkyl;
• each R2 is independently selected from the group consisting of C1-C6 alkyl, C3-C6 cycloalkyl, hydroxy, C1-C6 alkyl-hydroxy, C1-C6 alkoxy, halogen, C1-C6 haloalkyl, cyano, C1-C6 alkyl-cyano and oxo, or two R2 optionally join to form a heterocycle having 3-12 ring atoms or a C3-C6 cycloalkyl;
• each R3 is independently selected from the group consisting of C1-C6 alkyl, C3-C6 cycloalkyl, hydroxy, C1-C6 alkoxy, C1-C6 alkyl-hydroxy, halogen, C1-C6 halo-alkyl, N(R6)2, oxo and cyano, or two R3 optionally join to form a heterocycle having 3-12 ring atoms or C3-C6 cycloalkyl;
• R4 is —X—Y—Z where:
• X is absent or is selected from the group consisting of oxygen, sulfur and —NR6—,
• Y is absent or C1-C6 alkylenlyl, and
• Z is selected from H, —N(R6)2, —C(O)—N(R6)2, —OR6, heterocycle having 3-12 ring atoms, heteroaryl having 5-12 ring atoms, and C3-C6 cycloalkyl,
• where R4 is optionally substituted with one or more R7;
• each R5 is independently selected from the group consisting of:
• C1-C6 alkyl, hydroxy, C1-C6 alkoxy, halogen and —N(R6)2;
• each R6 is independently selected from the group consisting of hydrogen, hydroxyl, C1-C6 alkoxy and C1-C6 alkyl, or two R6 optionally join to form heterocycle having 3-12 ring atoms or C3-C6 cycloalkyl;
• each R7 is independently R7′ or C1-C6 alkyl-R7′, where each R7′ is independently selected from the group consisting of:
• C1-C6 alkyl, hydroxy, C1-C6 alkoxy, halogen, —N(R6)2, heterocycle having 3-12 ring atoms and oxo;
• and
• m is 0, 1, 2, 3, 4, 5, 6 or 7.