Certain chemical entities, compositions, and methods

A compound of Formula II

• or a pharmaceutically acceptable salt thereof, wherein
• R1, R2, R3, R5, R6, R7, R8, and R10 are independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted aryloxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or optionally substituted alkynyl;
• R4 is hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or optionally substituted alkynyl;
• and
• R9 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl;
• and R11 is hydroxyl, formyl, optionally substituted alkoxy, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, —COR12, —CO2R12, —CONR12R13, —C(NR14)NR12R13, —C(NCN)NR12R13, —SO2NR12, or —SO2NR12R13, where R12 is optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl;
• and R13 and R14 are independently hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl;
• or R12 and R13 may be joined together with any intervening atoms to form an optionally substituted heterocycloalkyl ring;
• or R9 and R11 may be joined together with any intervening atoms to form an optionally substituted heterocycloalkyl ring;
• wherein:
• each substituted acyl is —C(O)-(substituted alkyl), —C(O)-(substituted cycloalkyl), —C(O)-(substituted aryl), —C(O)-(substituted heteroaryl), or —C(O)-(substituted heterocycloalkyl);
• each substituted alkoxy is —O-(substituted alkyl);
• each substituted alkoxycarbonyl is —C(O)—O-(substituted alkyl);
• each substituted amino is —NHRd or —NRdRe;
• wherein each Rd is independently hydroxyl, formyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted acyl, unsubstituted or substituted carbamimidoyl, unsubstituted or substituted aminocarbonyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted alkoxycarbonyl, sulfinyl, and sulfonyl;
• and each Re is independently chosen from unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, or unsubstituted or substituted heterocycloalkyl;
• each substituted carbamimidoyl is —C(═NRe′)—NRfRg;
• wherein each Re′ is independently chosen from hydrogen, cyano, unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, or unsubstituted or substituted heterocycloalkyl;
• each Rf and Rg are independently hydrogen unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, or unsubstituted or substituted heterocycloalkyl;
• wherein at least one of Re′, Rf, and Rg is not hydrogen;
• and
• each substituted alkyl, substituted cycloalkyl, substituted aryl, substituted heterocycloalkyl, and substituted heteroaryl is substituted with one or more groups independently selected from —Ra, —ORb, —NH2, —NHRd, —NRdRe, —NRcCORb, —NRcCO2Ra, —NRcCONRbRc, —NRbC(NRc)NRbRc, —NRbC(NCN)NRbRc, —NRcSO2Rd, halo, cyano, azido, nitro, oxo (as a substituent for cycloalkyl or heterocycloalkyl), —CORb, —CO2Rb, —CONRbRc, —OCORb, —OCO2Rd, —OCONRbRc, —OP(O)(ORb)ORc, —SRb, —SORa, —SO2Ra, and —SO2NRbRc;
• each Ra is independently unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted aryl, or unsubstituted or substituted heteroaryl;
• each Rb is independently hydrogen, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted aryl, or unsubstituted or substituted heteroaryl;
• each Rc is independently hydrogen or unsubstituted or substituted C1-C4 alkyl;
• or Rb and Rc and the nitrogen to which they are attached, form an unsubstituted or substituted heterocycloalkyl group;
• each Rd is independently hydroxyl, formyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted acyl, unsubstituted or substituted carbamimidoyl, unsubstituted or substituted aminocarbonyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted alkoxycarbonyl, sulfinyl, and sulfonyl;
• and each Re is independently chosen from unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, or unsubstituted or substituted heterocycloalkyl;
• wherein when any Ra, Rb, Rc, Rd, Re, Re′, Rf, or Rg group is substituted, the Ra, Rb, Rc, Rd, Re, Re′, Rf, or Rg group is substituted with one or more substituents independently selected from a group D consisting of C1-C4 alkyl, aryl, heteroaryl, aryl-C1-C4 alkyl-, heteroaryl-C1-C4 alkyl-, C1-C4 haloalkyl, —OC1-C4 alkyl, —OC1-C4 alkylphenyl, —C1-C4 alkyl-OH, —OC1-C4 haloalkyl, halo, —OH, —NH2, —C1-C4 alkyl-NH2, —N(C1-C4 alkyl)(C1-C4 alkyl), —NH(C1-C4 alkyl), —N(C1-C4 alkyl)(C1-C4 alkylphenyl), —NH(C1-C4 alkylphenyl), cyano, nitro, oxo (as a substituent for cycloalkyl or heterocycloalkyl), —CO2H, —C(O)OC1-C4 alkyl, —CON(C1-C4 alkyl)(C1-C4 alkyl), —CONH(C1-C4 alkyl), —CONH2, —NHC(O)(C1-C4 alkyl), —NHC(O)(phenyl), —N(C1-C4 alkyl)C(O)(C1-C4 alkyl), —N(C1-C4 alkyl)C(O)(phenyl), —C(O)C1-C4 alkyl, —C(O)C1-C4 alkylphenyl, —C(O)C1-C4 haloalkyl, —OC(O)C1-C4 alkyl, —SO2(C1-C4 alkyl), —SO2(phenyl), —SO2(C1-C4 haloalkyl), —SO2NH2, —SO2NH(C1-C4 alkyl), —SO2NH(phenyl), —NHSO2(C1-C4 alkyl), —NHSO2(phenyl), and —NHSO2(C1-C4 haloalkyl).