Benzofuran derivatives for the treatment of CNS and other disorders

A compound of formula IV:

• wherein either
• R6 is selected from the group consisting of —NR3R4, —R3, —OR3 and halo;
• and
• R5 is —(CR═CR—)n(CR═CR2—)mR1,
• or
• R6 is —(CR═CR—)n(CR═CR2—)mR1;
• and
• R5 is selected from the group consisting of —NR3R4, —R3, —OR3 and halo,
• and
• further wherein m is 0 or 1, and
• wherein if m is 0, n is an integer from 1-10, and if m is 1, n is an integer from 0-10,
• R1 and R2 are independently selected from the group consisting of —H, —CN, —COOR, CONHR, CON(H)OR, —SO3R, —SO2R, —OSO3R, —PO3HR, and —OPO3HR, further wherein at least one of R1 and R2 is not —H;
• each R is independently selected from —H and C1-6 linear or branched alkyl;
• and
• R3 and R4 are independently selected from the group consisting of H, substituted or unsubstituted linear or branched C1-C10 alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted C6-C10 aryl, substituted or unsubstituted C5-C10 heteroaryl, substituted or unsubstituted C5-C10 cycloalkyl, and substituted or unsubstituted C5-C10 heterocycloalkyl;
• or R3 and R4 attached to their N together form a ring that is substituted or unsubstituted C5-C10 heterocycloalkyl;
• and wherein
• one of R1 and R2 is —CN and the other is —COOH;
• or
• R6 is —NR3R4, and R3 and R4 are substituted or unsubstituted phenyl.