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US 10,590,076 B2Granted
Hepatitis B capsid assembly modulators
AssigneeVenatorx Pharmaceuticals, Inc.
InventorsChristopher J. Burns, Glen Coburn, Bin Liu, Jiangchao Yao, Christopher Benetatos, Steven A. Boyd, Stephen M. Condon, Thomas Haimowitz
Life of this patent
Estimating the term…
Abstract
Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.
Claims17
A compound of Formula (I), or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof:
- wherein:
- Ring A is phenyl or pyridyl;
- each R11 is independently halogen, C1-C6alkyl, or C1-C6haloalkyl;
- R12 is hydrogen or C1-C6alkyl;
- R13 is hydrogen, halogen, or C1-C6alkyl;
- R14 is hydrogen, halogen, or C1-C6alkyl;
- R15 is hydrogen, C1-C6alkyl, C1-C6haloalkyl, or C1-C6hydroxyalkyl;
- R16 is hydrogen or C1-C6alkyl;
- R17 is cyclohexyl optionally substituted with one, two, or three R7;
- n is 0-3;
- each R7 is independently halogen, —CN, —OH, —ORa, —NRbRc, —C(═O)ORb, —C(═O)NRbRc, C1-C6alkyl, C1-C6haloalkyl, C1-C6hydroxyalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, —C1-C6alkyl(aryl), —C1-C6alkyl(heteroaryl), —C1-C6alkyl(cycloalkyl), or —C1-C6alkyl(heterocycloalkyl);
- wherein each alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one, two, or three R7a;
- each R7a is independently oxo, halogen, —CN, —OH, —ORa, —NRbRc, C1-C6alkyl, C1-C6haloalkyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- each Ra is independently C1-C6alkyl, C1-C6haloalkyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, C2-C6alkenyl, C2-C6alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- wherein each alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one, two, or three oxo, halogen, —CN, —OH, —OMe, —S(═O)Me, —S(═O)2Me, —NH2, —S(═O)2NH2, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C1-C6alkyl, C1-C6haloalkyl, C1-C6hydroxyalkyl, or C1-C6aminoalkyl;
- and
- each Rb and Rc are independently hydrogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, C2-C6alkenyl, C2-C6alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- wherein each alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one, two, or three oxo, halogen, —CN, —OH, —OMe, —S(═O)Me, —S(═O)2Me, —NH2, —S(═O)2NH2, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C1-C6alkyl, C1-C6haloalkyl, C1-C6hydroxyalkyl, or C1-C6aminoalkyl;
- or Rb and Rc are taken together with the atom to which they are attached to form a heterocycloalkyl optionally substituted with one, two, or three oxo, halogen, —CN, —OH, —OMe, —S(═O)Me, —S(═O)2Me, —NH2, —S(═O)2NH2, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C1-C6alkyl, C1-C6haloalkyl, C1-C6hydroxyalkyl, or C1-C6aminoalkyl.
16 more elements
Dependencies are inferred from the claim text.