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US 10,590,067 B2Granted
Alcohol derivatives of carboxamides as Kv7 potassium channel openers
AssigneeH. Lundbeck A/S
InventorsMario Rottlander, Anette Graven Sams, Xiaofang Wang, Debasis Das, Jian Hong, Shu Hui Chen
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Abstract
The present invention provides novel compounds which activate the Kv7 potassium channels. Exemplary compounds of the invention have the structure of Formula 1. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.
Claims27
A compound of Formula I
- wherein
- R1 is selected from the group consisting of methyl, ethyl, 1-propyl, 1-butyl, 2-butyl, t-butyl, CF3, CH2CF3, CF2CHF2, C3-C8 cycloalkyl, wherein said C3-C8 cycloalkyl may be substituted with 1 or 2 F, CHF2 or CF3, and
- R2 is H, —C1-C6 alkyl or CF3;
- or
- R1 and R2 combine to form C3-C5 cycloalkyl optionally substituted with 1 or 2 F, CHF2 or CF3;
- R3 is C1-C3 alkyl or CH2O—C1-3 alkyl, said C1-C3 alkyl or CH2O—C1-3 alkyl may optionally substituted with 1 or 2 F;
- and
- R4 is OCF3, OCH2CF3, OCHF2 or CF3.
5 more elements
Dependencies are inferred from the claim text.