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US 10,590,065 B2Granted
Biphenyl amides with modified ether groups as HSP90 inhibitors and HSP70 inducers
AssigneeUniversity of Kansas
InventorsBrian S. J. Blagg, Rick T. Dobrowsky, Mercy Anyika
Life of this patent
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Abstract
Provided herein are compounds of the formulas: (I) wherein: n, X2, R3, R3′, R4, R4′, R5, R5′, R6, and R6′ are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including diabetic peripheral neuropathy or cancer.
Claims13
A compound of the formula:
- wherein:
- the bond between atom 1 and atom 2 is either a single bond or a double bond;
- X2 is CH2— or —O—;
- R3, R4, R3′, R4′ are each independently hydrogen or hydroxy;
- R5 is a group of the formula:
- wherein:
- R10 is halo, alkyl(C≤8), or substituted alkyl(C≤8);
- R11 is halo, and
- x is 0 or 1,
- R5′ is hydrogen;
- R6 and R6′ are each independently hydrogen, alkyl(C≤12), or substituted alkyl(C≤12);
- and
- n is 1;
- or a pharmaceutically acceptable salt thereof.
11 more elements
Dependencies are inferred from the claim text.