Automated purification and formulation device for radiopharmaceutical compounds

A system for the formation, purification, and formulation of a radiopharmaceutical compound comprising:

• a radiosynthesizer device configured for synthesizing radiopharmaceutical compound;
• an automated purification subsystem comprising
• a computer controlled injection valve coupled to a high performance liquid chromatography (HPLC) pump, one or more sample loops, and an output line from the injection valve, the computer controlled injection valve having one or more ports configured to receive an input fluid containing the radiopharmaceutical compound from the radiosynthesizer device, wherein one of sample loops is connected to the HPLC pump and the output line from the injection valve;
• an automated column selector valve coupled to the output line from the injection valve and configured to select one of a plurality of columns for fluid to pass through;
• one or more detectors configured to receive an output of the selected column, the one or more detectors comprising at least a radiation detector;
• a downstream fraction selector valve disposed downstream with respect to the one or more detectors and configured to divert fluid flow to one of a product output, waste output, and fraction output;
• and
• an automated formulation subsystem coupled to the product output of the downstream fraction selector valve, the automated formulation subsystem comprising:
• a dilution reservoir configured to receive a product fraction from the downstream fraction selector valve, the dilution reservoir fluidically coupled to a solid-phase extraction cartridge;
• pumping means configured to push fluid contents contained in the dilution reservoir into the solid-phase extraction cartridge in response to actuation of the automated valve;
• a computer controlled pump coupled to a plurality of different fluid reagents and configured to pump selected fluid reagents through the solid-phase extraction cartridge via a computer controlled cartridge valve interposed between the dilution reservoir and the solid-phase extraction cartridge;
• a final output line fluidically coupled to an output of the solid-phase extraction cartridge, wherein a computer controlled waste valve is coupled to the final output line to divert fluid flow to waste or the final output line;
• and
• a computer accessible controller interfacing with the radiosynthesizer device, the automated purification subsystem, and the automated formulation subsystem, wherein one or more operations of the automated purification subsystem, the automated formulation subsystem, and the controller are programmable by a user.