Method and device for pacing latency based multi-point pacing

A system for controlling a pacing therapy utilizing left ventricular multi-point pacing (MPP), the system comprising:

• electrodes configured to be located proximate to an atrial (A) site, a right ventricular (RV) site and multiple left ventricular (LV) sites of the heart;
• memory to store program instructions;
• one or more processors configured to implement the program instructions to perform:
• determining atrial-ventricular conduction delays (AVCD) between the A site and multiple corresponding LV sites;
• determining pacing latencies at the LV sites;
• adjusting the AVCDs, based on the pacing latency at the corresponding LV sites, to form atrial-ventricular latency adjusted (ARPL) conduction delays for the corresponding LV sites;
• calculating interventricular pacing (VV) delays for combinations of the LV sites based on the corresponding ARPL conduction delays;
• and
• managing a pacing therapy, that utilizes left ventricular MPP, based on the VV delays for the corresponding LV sites;
• wherein the one or more processors are further configured to compare the pacing latencies at the LV sites to one or more thresholds and update a candidate LV site list based on the comparing operation.

A method for controlling a pacing therapy utilizing left ventricular multi-point pacing (MPP), the method comprising:

• providing electrodes configured to be located proximate to an atrial (A) site, a right ventricular (RV) site and multiple left ventricular (LV) sites of the heart;
• utilizing one or more processors to perform:
• determining atrial-ventricular conduction delays (AVCD) between the A site and multiple corresponding LV sites;
• determining pacing latencies at the LV sites, wherein the determining the AVCD further comprises determining an atrial-ventricular conduction delay (ARRV) between the A site and the RV site;
• adjusting the AVCDs, based on the pacing latency at the corresponding LV sites, to form atrial-ventricular latency adjusted (ARPL) conduction delays for the corresponding LV sites;
• calculating interventricular pacing (VV) delays for combinations of the LV sites based on the corresponding ARPL conduction delays;
• and
• managing a pacing therapy, that utilizes left ventricular MPP, based on the VV delays for the corresponding LV sites.

A method for controlling a pacing therapy utilizing left ventricular multi-point pacing (MPP), the method comprising:

• providing electrodes configured to be located proximate to an atrial (A) site, a right ventricular (RV) site and multiple left ventricular (LV) sites of the heart;
• utilizing one or more processors to perform:
• determining atrial-ventricular conduction delays (AVCD) between the A site and multiple corresponding LV sites;
• determining pacing latencies at the LV sites;
• comparing the pacing latencies at the LV sites to one or more thresholds and updating a candidate LV site list based on the comparing operation;
• adjusting the AVCDs, based on the pacing latency at the corresponding LV sites from the candidate LV site list, to form atrial-ventricular latency adjusted (ARPL) conduction delays for the corresponding LV sites;
• calculating interventricular pacing (VV) delays for combinations of the LV sites based on the corresponding ARPL conduction delays;
• and
• managing a pacing therapy, that utilizes left ventricular MPP, based on the VV delays for the corresponding LV sites.

A method for controlling a pacing therapy utilizing left ventricular multi-point pacing (MPP), the method comprising:

• providing electrodes configured to be located proximate to an atrial (A) site, a right ventricular (RV) site and multiple left ventricular (LV) sites of the heart;
• utilizing one or more processors to perform:
• determining atrial-ventricular conduction delays (AVCD) between the A site and multiple corresponding LV sites;
• determining pacing latencies at the LV sites, wherein the determining the AVCD further comprises determining an atrial-ventricular conduction delay (ARRV) between the A site and the RV site;
• adjusting the AVCDs, based on the pacing latency at the corresponding LV sites, to form atrial-ventricular latency adjusted (ARPL) conduction delays for the corresponding LV sites;
• calculating interventricular pacing (VV) delays for combinations of the LV sites based on the corresponding ARPL conduction delays;
• and
• managing a pacing therapy, that utilizes left ventricular MPP, based on the VV delays for the corresponding LV sites, further comprising calculating ΔARPL differences between the ARPL conduction delays for combinations of the LV sites, comparing the ΔARPL differences with one or more thresholds and updating a candidate LV site list based on the comparing operation, the candidate LV site list maintaining a list of candidate LV sites to deliver pacing therapy.

A method for controlling a pacing therapy utilizing left ventricular multi-point pacing (MPP), the method comprising:

• providing electrodes configured to be located proximate to an atrial (A) site, a right ventricular (RV) site and multiple left ventricular (LV) sites of the heart;
• utilizing one or more processors to perform:
• determining atrial-ventricular conduction delays (AVCD) between the A site and multiple corresponding LV sites;
• determining pacing latencies at the LV sites;
• adjusting the AVCDs, based on the pacing latency at the corresponding LV sites, to form atrial-ventricular latency adjusted (ARPL) conduction delays for the corresponding LV sites;
• calculating interventricular pacing (VV) delays for combinations of the LV sites based on the corresponding ARPL conduction delays;
• and
• managing a pacing therapy, that utilizes left ventricular MPP, based on the VV delays for the corresponding LV sites, the managing the pacing therapy utilizes a first VV delay to deliver pacing pulses to a first LV site and a second VV delay to deliver pacing pulses to a second LV site.