Methods for producing respirable dry powders

A process for producing one or more receptacles with a respirable dry powder disposed therein, comprising

• disposing the respirable dry powder into a plurality of said receptacles at a target fill weight and at a rate of about one receptacle every 4 seconds or less to produce filled receptacles, wherein at least 80% of said filled receptacles contain said respirable dry powder within 85% to 115% of the target fill weight;
• and
• wherein the respirable dry powder consists of respirable dry particles that have a volume median geometric diameter (VMGD) of about 10 micrometers or less, and a tap density of at least about 0.45 g/cubic centimeters, and wherein the respirable dry particles comprise a sodium salt and one or more therapeutic agent that provides at least about 25% of the total mass of the contents disposed within the receptacle, with the proviso that the respirable dry particles do not contain a divalent metal cation salt.