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US 10,589,004 B2Granted
Materials for soft and hard tissue repair
OwnerBarry K. Bartee, Richard A. Roseninventors
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Abstract
Biomaterials and methods and uses for repair or augmentation of tissues are provided. In particular, the invention provides a multi-layered, naturally occurring multi-axial oriented biomaterial comprising predominately type I collagen fibers. The invention further provides methods and uses for repair or augmentation of tissues using biomaterials of the invention.
Claims24
A method for manufacture of a biomaterial suitable for tissue repair or augmentation, comprising:
- selecting naturally-occurring muscular fascia comprising multi-layered, multi-axial oriented biomaterial that mimics composition and structure of tissue to be repaired or augmented, wherein the muscular fascia includes type I collagen fibers;
- configuring the selected muscular fascia to provide a multiaxial tensile strength of at least 20 N/cm;
- and
- chemically adding crosslinks to one or more layers of the muscular fascia to obtain a crosslinked biomaterial that mimics a mechanical characteristic of the tissue to be repaired or augmented, wherein the selected muscular fascia includes type I collagen fibers within each layer that are axially aligned in different directions from other type I collagen fibers within the each layer,
- wherein the muscular fascia is a xenograft with respect to a recipient of the biomaterial.
2 more elements
A biomaterial comprising:
- muscular fascia comprising multiple layers of naturally-occurring type I collagen fibers configured to provide a multiaxial tensile strength of at least 20 N/cm and adapted to mimic composition and structure of tissue to be repaired or augmented and to mimic a mechanical property of the tissue to be repaired or augmented,
- wherein the muscular fascia is a xenograft with respect to a recipient of the biomaterial,
- wherein one or more layers of the muscular fascia include chemically added crosslinks, and wherein the muscular fascia includes type I collagen fibers within each layer that are axially aligned in different directions from other type I collagen fibers within the each layer.
Dependencies are inferred from the claim text.