Methods for coating surfaces with antimicrobial agents
AssigneeBoard of Regents, The University of Texas System
InventorIssam Raad
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Abstract
Disclosed are methods for coating or impregnating a surface with an antimicrobial agent that involve contacting the surface with a composition that includes an antimicrobial agent and a solvent, and curing the surface by applying heat. Also disclosed are methods for reducing the risk of development or progression of an infection in a subject in need of a medical device, that involve coating or impregnating a surface of the medical device with an antimicrobial agent and then curing the surface by applying heat, wherein the risk of development or progression of an infection is reduced.
Claims18
A method for coating or impregnating a non-organic surface with minocyline and rifampin, comprising:
- a) mixing the minocycline and rifampin drugs with a solvent to form a mixture and heating the mixture sufficient to dissolve the minocycline and rifampin in the solvent to form a drug-solvent solution;
- b) placing the non-organic surface into the drug-solvent solution for a period of time to coat the non-organic surface with the drugs;
- c) taking the coated non-organic surface out of the solution and curing it at a temperature that removes at least some of the solvent from the non-organic surface;
- d) drying the cured surface of step c);
- and
- e) heating the dried surface of step d) at a temperature of at least 50° C. for at least 12 hours to provide the coated or impregnated non-organic surface.
Dependencies are inferred from the claim text.