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AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsHongbin Jiang, William R. Wagner, Tomo Yoshizumi, Yang Zhu
Estimating the term…
Provided are novel biocompatible copolymers, compositions comprising the copolymers, and methods of using the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.
A composition, comprising a copolymer having a lower critical solution temperature (LCST) of less than 37° C., comprising N-isopropyl acrylamide (NIPAAm) residues;
A method of treating a myocardial defect in a patient comprising injecting a composition comprising a copolymer having a lower critical solution temperature (LCST) of less than 37° C., comprising:
Dependencies are inferred from the claim text.