US 10,589,001 B2 · Pharmaceutical formulation for use in spinal fusion

Abstract

A pharmaceutical formulation for use in a spinal fusion method, comprising a composition for forming a matrix, a kit comprising the composition, a pharmaceutical product obtainable from the pharmaceutical formulation, and an interbody spinal fusion cage containing the pharmaceutical formulation or the pharmaceutical product are described herein. The composition comprises at least a first matrix material precursor component and a second matrix material precursor component that are able to crosslink to form the matrix under appropriate conditions, a bioactive factor that is biologically active for stimulating bone formation between two vertebrae and for effecting or supporting spinal fusion. The bioactive factor is PTH, optionally a PTH fusion peptide. The bioactive factor is releasably incorporated in the matrix upon crosslinking of the matrix material precursor components.

Claims14

Dependent claims

A spinal fusion method for treatment of a human patient in need thereof, comprising

administering to the patient at a site between two adjacent vertebrae in need of spinal fusion a pharmaceutical composition capable of forming under physiological conditions a bone graft substitute,
wherein the pharmaceutical composition comprises one or more matrix forming materials and parathyroid hormone (PTH), wherein the composition does not contain any additional added peptide or protein bioactive factor with bone forming properties,
wherein during or after administration, the pharmaceutical composition forms a bone graft substitute at the site,
wherein the bone graft substitute comprises a matrix and the PTH, and does not contain any additional added peptide or protein bioactive factor with bone forming properties,
and
wherein the bone graft substitute locally delivers the PTH to the site in an effective amount to achieve bone formation between the vertebrae.

3 more elements

Dependencies are inferred from the claim text.

Pharmaceutical formulation for use in spinal fusion

Life of this patent

Pharmaceutical formulation for use in spinal fusion

Life of this patent

Abstract

Claims14