Polymer nanofiber scaffolds and uses thereof

A wound dressing comprising:

• a plurality of melt extruded polymer nanofibers and at least one peptide conjugated to the nanofibers, the nanofibers each having a rectangular cross-section defined in part by an encapsulating polymer material that is separated from the nanofibers, the nanofibers including a plurality of click-reactive functional groups of a specific binding pair extending from portions of outer surfaces of the nanofibers, the click-reactive functional groups being chemically bound to the nanofibers without degrading polymers chains of the nanofibers and the at least one peptide being conjugated to a complementary click-reactive group that is appended to the specific binding pair of the click-reactive functional groups of the nanofibers to conjugate the at least one peptide to the nanofibers.