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US 10,588,984 B2Granted
Virus-like particle conjugates for diagnosis and treatment of tumors
AssigneesAura Biosciences, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsElisabet de los Pinos, John Todd Schiller, Rhonda C. Kines, John MacDougall
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Abstract
The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.
Claims21
A method of producing tumor-targeting bioconjugates, the method comprising:
- (a) transfecting cells in vitro with deoxyribonucleic acid (DNA) encoding papilloma virus capsid proteins, wherein expression of the DNA in the cells results in production of the papilloma virus capsid proteins, and the papilloma virus capsid proteins assemble to form proto-capsids;
- (b) collecting the proto-capsids and subjecting the proto-capsids to a maturation process to form virus-like particles comprising the papilloma virus capsid proteins;
- and
- (c) conjugating near infrared phthalocyanine dye molecules to papilloma virus capsid proteins of the virus-like particles, thereby producing the tumor-targeting bioconjugates, each comprising about 50 to about 1000 near infrared phthalocyanine dye molecules, wherein the near infrared phthalocyanine dye molecules become toxic or produce a toxic molecule upon light activation.
1 more element
Dependencies are inferred from the claim text.