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US 10,588,982 B2Granted
Site-specific covalent chemical ligation to monoclonal and polyclonal immunoglobulin
AssigneeThe Regents of the University of California
InventorsDiana Lac, Chun Feng, Gaurav Bhardwaj, Siddarth Chandrasekaran, Kit S. Lam
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Abstract
Methods and compositions are described herein for covalently linking an antibody to a molecular payload. Compositions are described herein containing an antibody covalently linked to a molecular payload.
Claims21
A compound comprising:
- i) a targeting moiety that specifically binds a nucleotide binding pocket of an antibody;
- ii) a cross-linking agent;
- iii) an active agent or a conjugating agent;
- and
- iv) a linker, wherein the linter comprises an amino acid sequence, and the amino acid sequence comprises negatively charged amino acids, and wherein the linker covalently links:
- a) the targeting moiety,
- b) the cross-linking agent, and
- c) the active agent or conjugating agent.
5 more elements
Dependencies are inferred from the claim text.