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US 10,588,977 B2Granted
Preserved compositions containing hyaluronic acid or a pharmaceutically-acceptable salt thereof and related methods
AssigneeJohnson & Johnson Consumer Inc.
InventorsUday Doshi, Kenneth T. Holeva
Life of this patent
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Abstract
The invention provides a composition containing hyaluronic acid (HA) or a pharmaceutically-acceptable salt thereof preserved with a cationic preservative and related methods. In one embodiment, the pharmaceutically-acceptable salt is sodium hyaluronate. In another embodiment, the cationic preservative includes benzalkonium chloride (BAK).
Claims2
A method for preparing a preserved hyaluronic acid composition, the method comprising:
- dissolving a cationic preservative in a first quantity of a solvent;
- dissolving a quantity of hyaluronic acid (HA) or physiologically-acceptable salt thereof in a second quantity of the solvent;
- and
- adding the dissolved HA or physiologically-acceptable salt thereof to the dissolved cationic preservative,
- wherein precipitation of the cationic preservative and the HA or physiologically-acceptable salt thereof is substantially prevented by dissolving each in the first and second quantities of solvent before they are combined, wherein the cationic preservative is selected from salts of alexidine, alexidine-free base or mixtures thereof and further wherein the first quantity of the solvent and the second quantity of the solvent are combined at a ratio, the ratio of the first quantity of the solvent to the second quantity of the solvent being between about 1.8:1 and about 2.2:1.
2 more elements
A method for preparing a preserved hyaluronic acid composition, the method comprising:
- dissolving a cationic preservative in a first quantity of a solvent;
- dissolving a quantity of hyaluronic acid (HA) or physiologically-acceptable salt thereof in a second quantity of the solvent;
- and
- adding the dissolved HA or physiologically-acceptable salt thereof to the dissolved cationic preservative,
- wherein precipitation of the cationic preservative and the HA or physiologically-acceptable salt thereof is substantially prevented by dissolving each in the first and second quantities of solvent before they are combined, wherein the cationic preservative is selected from salts of alexidine, alexidine-free base or mixtures thereof and further wherein the first quantity of the solvent and the second quantity of the solvent are combined at a ratio, the ratio of the first quantity of the solvent to the second quantity of the solvent being about 2:1.
2 more elements
Dependencies are inferred from the claim text.