Localized immunosuppression of allografts for peripheral nerve repair
AssigneeUniversity of Wyoming
InventorJared Bushman
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Abstract
Embodiments described herein relate to restorative solutions for segmental peripheral nerve (PN) defects using allografted PNs for stimulating PN repair. More specifically, embodiments described herein provide for localized immunosuppression (LIS) surrounding PN allografts as an alternative to systemically suppressing a patient's entire immune system. Methods include localized release of immunosuppressive (ISV) agents are contemplated in one embodiment. Methods also include localized application of immunosuppressive (ISV) regulatory T-cells (Tregs) in other embodiments. Hydrogel carrier materials for delivery of ISV agents and are also described herein.
Claims20
A method of peripheral nerve grafting, comprising:
- delivering one or both of T-regs and mesenchymal stromal cells to a peripheral nerve allograft site via a pharmaceutically acceptable carrier.
A method of peripheral nerve grafting, comprising:
- delivering a calcineurin inhibitor to a peripheral nerve allograft site in vivo;
- delivering a glucocorticoid to the peripheral nerve allograft site in vivo;
- and
- delivering one or both of Tregs and mesenchymal stromal cells to the peripheral nerve allograft site in vivo, wherein the calcineurin inhibitor, the glucocorticoid, and the one or both of the Tregs and the mesenchymal stromal cells are delivered locally to the peripheral nerve allograft site by a pharmaceutically acceptable carrier.
A method of peripheral nerve grafting, comprising:
- locally delivering to a peripheral nerve allograft site via a hydrogel material, an immunosuppressive agent comprising a calcineurin inhibitor, a glucocorticoid, Tregs, and mesenchymal stromal cells.
Dependencies are inferred from the claim text.