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US 10,588,968 B2Granted
Human anti-VEGFR-2/KDR antibodies
AssigneeKadmon Corporation, LLC
InventorsDan Lu, Zhenping Zhu
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Abstract
The invention relates to antibodies that bind to VEGFR-2. The antibodies are used for treating neoplastic diseases, hyperproliferative disorders, and angiogenic disorders and can be used alone or in combination with other agents.
Claims13
An isolated antibody or antigen binding fragment thereof that binds to human VEGFR2, comprising a heavy chain variable domain, which comprises a CDR1H, a CDR2H, and a CDR3H sequence, and a light chain variable domain, which comprises a CDR1L, a CDR2L, and a CDR3L sequence wherein:
- (i) the CDR1H sequence is GFTFSWYVMG (SEQ ID NO:
- 237);
- (ii) the CDR2H sequence is SIYPQGGATSYADSVKG (SEQ ID NO:
- 238);
- (iii) the CDR3H sequence is GNYFDY (SEQ ID NO:
- 241);
- (iv) the CDR1L sequence is RASQSVSSNYFG (SEQ ID NO:
- 245);
- (v) the CDR2L sequence is GASSRAT (SEQ ID NO:
- 246);
- and
- (vi) the CDR3L sequence is QQFDSLPLT (SEQ ID NO:
- 247).
10 more elements
Dependencies are inferred from the claim text.