Bacterial RNAs as vaccine adjuvants
AssigneeCornell University
InventorsJulie Magarian Blander, Leif Erik Sander
Life of this patent
Estimating the term…
Abstract
The invention features vaccine adjuvants comprising prokaryotic mRNA, and methods of vaccination using the adjuvants.
Claims18
A vaccine composition comprising a tumor antigen and an adjuvant, wherein said adjuvant comprises prokaryotic mRNA, wherein the prokaryotic mRNA has structural features comprising a 3′ stem loop structure, intramolecular base-pairing, and no 3′ poly(A) tail.
A vaccine composition comprising an immunogenic peptide of microbial or mammalian origin and an adjuvant, wherein said adjuvant comprises prokaryotic mRNA, wherein the prokaryotic mRNA has structural features comprising a 3′ stem loop structure, intramolecular base-pairing, and no 3′ poly(A) tail.
An immunization kit, comprising a vaccine composition comprising a tumor antigen, and an adjuvant composition comprising prokaryotic mRNA, wherein the prokaryotic mRNA has structural features comprising a 3′ stem loop structure, intramolecular base-pairing, and no 3′ poly(A) tail.
Dependencies are inferred from the claim text.