Vaccine compositions
AssigneeBharat Biotech International Limited
InventorsKandaswamy Sumathy, Krishna Murthy Ella
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Abstract
The present disclosure provides vaccine compositions for prophylaxis and treatment of Zika virus infections comprising Zika virus antigens in immunogenic compositions, and in combination of Zika antigens with one or more arbovirus antigens such as Chikungunya virus and Japanese encephalitis virus antigens, methods of preparation and production of such compositions for use as vaccines for eliciting immune response in mammals against the above mentioned pathogens.
Claims54
An immunogenic composition comprising an antigen obtained or derived from a Zika virus, and a pharmaceutically acceptable buffer, wherein said antigen is rendered non-infectious through a non-natural inactivation, and
- wherein the composition elicits a protective immune response to Zika virus in mammals.
A stable immunogenic composition comprising:
- a recombinantly engineered antigen obtained or derived from nucleic acid of a Zika virus, and
- a pharmaceutically acceptable buffer,
- wherein the composition elicits a protective immune response to infection by Zika virus in mammals.
An immunogenic composition comprising an antigen obtained or derived from a Zika virus, and a pharmaceutically acceptable buffer, wherein:
- said antigen is rendered non-infectious through non-natural inactivation and/or is recombinantly engineered from the nucleic acid of a Zika virus;
- and
- said antigen contains the amino acid sequence of SEQ ID NO 3 and/or SEQ ID NO 4.
Dependencies are inferred from the claim text.