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US 10,588,955 B2Granted
Streptococcus pneumoniae protein antigen, and preparation method and use thereof
AssigneesChangchun BCHT Biotechnology Co., Jilin University
InventorsWei Kong, Yongge Wu, Jingcai Lu, Tianxu Sun, Man Xu, Dandan Wang, Hongjia Hou, Yunliang Dong
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Abstract
Provided are a fusion protein of a pneumococcal surface adhesin A (PsaA) and a pneumococcal surface protein A (PspA), and preparation method and use thereof. Also provide are a nucleic acid for encoding the protein, carrier and cell for expressing the protein, and vaccine composition comprising the protein.
Claims18
A fusion protein comprising a Pneumococcal surface adhesion A (PsaA) and a Pneumococcal surface protein A (PspA), wherein the PsaA has an amino acid sequence as shown in SEQ ID NO:
- 1;
- and the PspA comprises a part of PspA Clade2 wherein said part of PspA Clade2 comprises SEQ ID NO:
- 2 and a part of PspA Clade3 wherein said part of PspA Clade3 comprises SEQ ID NO:
- 3.
1 more element
Dependencies are inferred from the claim text.