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US 10,588,954 B2Granted
Anti-malaria compositions and methods
AssigneeArtificial Cell Technologies, Inc.
InventorsJames Gorham Boyd, Thomas J. Powell
Life of this patent
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Abstract
Described herein are multilayer films that include modified polypeptide epitopes from Plasmodium falciparum, specifically a modified T* epitope. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films can include at least one designed peptide that includes the modified T* polypeptide epitope from a Plasmodium protozoan.
Claims13
A method of eliciting an immune response in a vertebrate organism comprising administering into the vertebrate organism a composition comprising
- a multilayer film comprising a plurality of oppositely charged polyelectrolyte layers,
- wherein one of the polyelectrolyte layers in the multilayer film comprises a first antigenic polyelectrolyte,
- wherein the first antigenic polyelectrolyte comprises a modified Plasmodium falciparum circumsporozoite T* epitope of SEQ ID NO:
- 5, and
- wherein the polyelectrolytes in the multilayer film comprise a polycationic material or a polyanionic material having a molecular weight of greater than 1,000 and at least 5 charges per molecule.
2 more elements
Dependencies are inferred from the claim text.