Compositions and methods related to xCT peptides
AssigneeAgilvax Inc.
InventorsFederica Cavallo, Stefania Lanzardo, Laura Conti, John P. O'Rourke, Federica Pericle
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Abstract
Certain embodiments are directed to composition for inducing an immune response against xCT that is directed to cancer stem cells expressing xCT.
Claims13
An RNA-bacteriophage virus-like particle (VLP) comprising a single chain dimeric coat protein having an xCT peptide insertion, wherein the xCT peptide has an amino acid sequence of KGQTQNFKDAFSGRDSSITRLP (SEQ. ID NO:9), GDLDSLLN (SEQ. ID NO:11) and/or LYSDPFST (SEQ. ID NO:12).
An immunogenic composition comprising an RNA bacteriophage VLP displaying an xCT peptide, wherein the xCT peptide has an amino acid sequence of KGQTQNFKDAFSGRDSSITRLP (SEQ. ID NO:9), GDLDSLLN (SEQ. ID NO:11), and/or LYSDPFST (SEQ. ID NO:12).
Dependencies are inferred from the claim text.