Ultrapure hypoallergenic solutions of sacrosidase
AssigneeQOL Medical LLC
InventorsDayton T. Reardan, Christopher Seekamp
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Abstract
The invention provides a method for treating a subject who lacks endogenous sucrase activity by orally administering a solution of sacrosidase in about 1:1 glycerol/water having an enzymatic activity of at least about 7500 IU/mL and a residual papain concentration of less than about 10 ng/ml.
Claims10
A method for treating a subject who lacks endogenous sucrase activity, comprising orally administering an effective amount of a protein composition consisting essentially sacrosidase having a band volume ratio of sacrosidase to other proteins comprising papain of at least about 35:1 by SDS-PAGE of about 20 μg of said composition, wherein the primary structure of the sacrosidase is a 513 amino acid polypeptide that is gycosylated.
A method of treating a subject who lacks endogenous sucrase activity comprising orally administering an effective amount of a protein composition consisting essentially of sacrosidase derived from Saccharomyces having residual papain in a concentration of less than about 10 ng/mL, papain, and having a band volume ratio of sacrosidase to other proteins comprising papain of at least about 35:1 by SDS-PAGE of about 20 μg of said composition, wherein the primary structure of the sacrosidase is a 513 amino acid polypeptide that is glycosylated.
Dependencies are inferred from the claim text.