Modulation of CCR10 signals for treatment of skin and intestinal inflammatory diseases and infection
AssigneeThe Penn State Research Foundation
InventorsNa Xiong, Mingcan Xia
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Abstract
The invention provides compositions and methods for targeting CCR10 and/or the CCR10/ligand axis to modulate the immune response in a subject.
Claims2
A method of modulating an immune response in a mammal suffering from colitis, the method comprises administering to the mammal in need thereof an effective amount of a composition comprising an activator of CCR10, wherein the activator comprises CCL28 protein.
A method of inhibiting an immune response in a mammal suffering from colitis, the method comprising administering to the mammal in need thereof an effective amount of a composition comprising an activator of CCR10, wherein the activator is CCL28.
Dependencies are inferred from the claim text.