Modulators of complement activity
AssigneeRa Pharmaceuticals, Inc.
InventorsMichelle Denise Hoarty, Ketki Ashok Dhamnaskar, Daniel Elbaum, Kristopher Josephson, Kelley Cronin Larson, Zhong Ma, Nathan Ezekiel Nims, Alonso Ricardo, Kathleen Seyb, Guo-Qing Tang, Douglas A. Treco, Zhaolin Wang, Ping Ye, Hong Zheng, Sarah Jacqueline Perlmutter
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Abstract
The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.
Claims20
A method of reducing complement activity associated with coagulation, the method comprising reducing C5 cleavage, by contacting a C5 system with a polypeptide comprising amino acid residues 9-12 of SEQ ID NO:
- 192.
A method of reducing complement activity in a subject, wherein the complement activity is associated with coagulation, the method comprising administering a polypeptide to the subject, thereby reducing complement activity in the subject, wherein the polypeptide comprises amino acid residues 9-12 of SEQ ID NO:
- 192.
Dependencies are inferred from the claim text.