Daphne laureola extracts in the treatment of dermopathies

A method for treating a dermopathy or a skin disease characterized by cell hyperproliferation comprising topically administering to an individual in need thereof a pharmaceutical, cosmetic or cosmeceutical formulation comprising:

• (a) a phytocomplex concentrate extracted from a Daphne laureola plant or plant part, wherein the phytocomplex concentrate is present in the pharmaceutical, cosmetic or cosmeceutical formulation in an amount sufficient to treat the dermopathy or the skin disease characterized by cell hyperproliferation, and
• (b) a pharmaceutically, cosmetically or cosmeceutically acceptable component or a topical emollient,
• wherein the phytocomplex concentrate is prepared from the Daphne laureola plant or plant part by a method comprising:
• (1)
• (i) preparing an infusion of the Daphne laureola plant or plant part by a method comprising steeping the Daphne laureola plant or plant part in previously boiled water or a polar solvent, thereby extracting the phytocomplex into the water or polar solvent;
• (ii) preparing a decoction of the Daphne laureola plant or plant part by a method comprising steeping the Daphne laureola plant or plant part in cold water, then bring the water to a boil, thereby extracting the phytocomplex into the water;
• (iii) steeping the Daphne laureola plant or plant part in an alcoholic or hydroalcoholic solution, thereby extracting the phytocomplex into the alcoholic or hydroalcoholic solution;
• (iv) contacting the Daphne laureola plant or plant part with a supercritical fluid, thereby extracting the phytocomplex into the supercritical fluid;
• (v) percolating the Daphne laureola plant or plant part in a polar solvent under continuous agitation, optionally assisted by ultrasound and/or microwave, thereby extracting the phytocomplex into the polar solvent;
• or
• (vi) any combination of (i) to (v);
• and
• (2) preparing the phytocomplex concentrate from the water, polar solvent, alcoholic or hydroalcoholic solution, or supercritical fluid by removing all or a portion of the water, polar solvent, alcoholic or hydroalcoholic solution, or supercritical fluid,
• wherein optionally the concentrate of the phytocomplex is prepared by a method comprising evaporation of the water, polar solvent, alcoholic or hydroalcoholic solution, or supercritical fluid, or lyophilization of the phytocomplex-comprising water, polar solvent, alcoholic or hydroalcoholic solution, or supercritical fluid,
• and optionally the concentrate comprises a liquid, a semisolid or a dry extract, wherein the pharmaceutical, cosmetic or cosmeceutical is formulated for topical application,
• thereby treating the dermopathy or the skin disease characterized by cell hyperproliferation.