Aqueous suspension agent containing glucocorticosteroid nanoparticles
AssigneeActivus Pharma Co., Ltd.
InventorsTakahiro Tada, Kazuhiro Kagami, Kenta Kikuchi
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Abstract
An aqueous suspension containing as an active component a glucocorticosteroid compound is described. The aqueous suspension contains nanoparticles of a glucocorticosteroid compound and a dispersion stabilizer. The nanoparticles have a mean particle diameter of 300 nm or less and a D90 particle diameter of 450 nm or less. The pharmaceutical compositions containing the aqueous suspension are for parenteral administrations, injections, eye drops or ear drops. More specifically the aqueous suspensions containing glucocorticosteroid nanoparticles are used as an eye drop for treating or preventing inflammatory diseases of the eye or an ear drop for treating or preventing inflammatory diseases of the ear.
Claims16
An aqueous suspension comprising:
- nanoparticles of a glucocorticosteroid compound;
- a physiologically acceptable salt;
- glycerin;
- hydrogenated soybean lecithin;
- and
- anhydrous citric acid;
- wherein a mean particle diameter of the nanoparticles is 300 nm or less and a D90 particle diameter of the nanoparticles is 450 nm or less.
An aqueous suspension comprising nanoparticles of a glucocorticosteroid compound, wherein a mean particle diameter of the nanoparticles is 300 nm or less and a D90 particle diameter of the nanoparticles is 450 nm or less, and the nanoparticles are produced by mixing the glucocorticosteroid compound, a physiologically acceptable salt, glycerin, hydrogenated soybean lecithin and anhydrous citric acid.
Dependencies are inferred from the claim text.