Pharmaceutical composition comprising epidithiodioxopiperazine compound or derivative thereof, or pharmaceutically acceptable salt thereof, for preventing or treating pulmonary hypertension

A method for preventing or treating pulmonary arterial hypertension, comprising administering a pharmaceutical composition to a subject in need thereof,

• wherein the pharmaceutical composition comprises an epidithiodioxopiperazine compound represented by the following Formula 1 or a derivative thereof, a natural product-derived epidithiodioxopiperazine derivative, or a pharmaceutically acceptable salt thereof, which has an intramolecular disulfide bond in an epidithiodioxopiperazine ring as an active ingredient,
• wherein the natural produced-derived epidithiodioxopiperazine derivative is any one of compounds represented by the following Formulas 2 to 17:
• wherein, in Formula 1 above,
• R1 to R4 are each independently hydrogen, linear or branched C1 to C6 alkyl, alkenyl or alkynyl, linear or branched C1 to C6 alkoxy, linear or branched C1 to C6 hydroxyalkyl, substituted or unsubstituted benzyl, linear or branched C1 to C6 alkylaryl, or a substituted or unsubstituted aryl group,
• and the alkyl comprises or does not comprise an oxygen atom in the middle of the chain.