Methods of treating pediatric cancers

A method of treating a Trk-associated pediatric cancer in a subject in need thereof, wherein the cancer is selected from the group comprising congenital mesoblastic nephroma, Ph-like acute lymphoblastic leukemia, infantile fibrosarcoma, pediatric high-grade glioma (HGG), diffuse intrinsic pontine gliomas (DIPGs), pediatric papillary thyroid carcinoma, soft tissue sarcoma, and spindle cell sarcoma, the method comprising:

• (a) administering to the subject a therapeutically effective amount of (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide having the formula (I):
• a pharmaceutically acceptable salt thereof, or combinations thereof;
• and
• (b) performing surgical resection on the pediatric cancer;
• wherein the compound of formula (I), a pharmaceutically acceptable salt thereof, or combinations thereof, is provided as a liquid formulation comprising:
• a solubilizing agent, wherein the solubilizing agent comprises a β-cyclodextrin;
• and
• a base;
• wherein:
• the formulation has a pH of about 2.5 to about 5.5;
• and
• the compound of formula (I) has a concentration of about 15 mg/mL to about 35 mg/mL in the liquid formulation.