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US 10,588,903 B2Granted
Methods and compositions for enhancing immune response to vaccination
AssigneesEmv Enhance (Hk) Limited, Versitech Limited
InventorsFan Ngai Hung, Jinxia Zhang, Kai Wang Kelvin To, Johnson Yiu-Nam Lau, Kwok Yung Yuen
Life of this patent
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Abstract
Compositions and methods are described in which the topical application of a toll-like receptor 7 agonist or a toll-like receptor 9 agonist at or near a subdermal vaccination site provides an enhanced response to the vaccination. The enhanced response can be an elevated antibody titer relative to an untreated but vaccinated subject, and/or development of cross-species immunity to species not present in the vaccinating composition.
Claims11
A method for improving an immune response to vaccination, comprising:
- applying a formulation that is delivered topically to a vaccination site at or immediately prior to vaccination, the topical formulation comprising a toll-like receptor 7 agonist or a toll-like receptor 9 agonist;
- introducing an influenza vaccine at the vaccination site, the influenza vaccine comprising a vaccinating influenza strain;
- and
- removing the topical formulation from the vaccination site after a time interval,
- wherein the topical formulation is selected to provide the toll-like receptor 7 agonist or the toll-like receptor 9 agonist in a quantity sufficient to provide effective antibody response against a non-vaccinating influenza strain that is not present in the influenza vaccine.
2 more elements
Dependencies are inferred from the claim text.