Back to results
US 10,588,902 B2Granted
Camptothecin derivatives as anti-HIV agents and methods of identifying agents that disrupt Vif self-association
AssigneeOyagen, Inc.
InventorsHarold C. Smith, Ryan P. Bennett
Life of this patent
Estimating the term…
Abstract
The present invention relates to the use of camptothecin derivatives as anti-HIV agents that disrupt self-association of the viral infectivity factor (Vif) found in HIV and other retroviruses. The present invention also relates to methods of identifying agents that disrupt VIf self-association and methods of using these agents, including methods of treating or preventing HIV infection.
Claims2
A method for treating HIV infection in a patient by inhibiting Vif self-association in a cell, said method comprising:
- administering to a patient in need of such treatment a therapeutically effective amount of a compound of Formula (I-a):
- or a pharmaceutically acceptable salt thereof.
A method for inhibiting infectivity of a lentivirus in a cell, said method comprising:
- contacting a cell with an antiviral-effective amount of a compound of Formula (I-a):
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.