Combination therapy

A composition comprising:

• a) a dimesylate salt of a compound according to formula (I):
• wherein:
• R1 and R2 are, independently, hydrogen or C1-C4 alkyl, or R1 and R2 are taken together with the nitrogen atom to which they are attached to form a ring of 3, 4, 5, 6, 7 or 8 member atoms;
• A is —CH2NH—, —CH(R10)—, —C(CH3)R10)—, —CH2CH2—, —CH(R10)CH2—, —CH2CH2CH(R10)—, —CH2CH(R10)—, or —C(CH3)(R10)CH2—;
• each R10 is, independently, unsubstituted alkyl, substituted alkyl, unsubstituted alkenyl, substituted alkenyl, unsubstituted alkynyl, substituted alkynyl, unsubstituted amino, substituted amino, unsubstituted aryl, substituted aryl, unsubstituted heteroaryl, substituted heteroaryl, unsubstituted cycloalkyl, substituted cycloalkyl, unsubstituted heterocycloalkyl, or substituted heterocycloalkyl, any of which may be optionally substituted;
• and
• X1 and X2 are, independently, hydrogen, hydroxy, halogen, alkyl, amino, nitro, cyano, carbonylamino, alkoxy, aryloxy, sulfonyl, sulfonamido, thioalkyl, or carboxyl;
• wherein a substituted group refers to any substitutable atom of that group substituted, independently, with an acyl, alkoxy, alkyl, alkenyl, alkynyl, amino, aryl, arylalkyl, carbonylamino, carboxyl, cycloalkyl, cycloalkylalkyl, cyano, halo, haloalkyl, heteroalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, hydroxy, nitro, oxo, phosphonate, sulfinyl, sulfonyl, sulfonate, sulfonamide, thioamido, thiol, thioalkyl, thioxo, or ureido;
• and
• b) a prostaglandin or a prostaglandin analog;
• wherein:
• the prostaglandin is any compound having a prostanoic acid skeleton:
• and
• the prostaglandin analog is a compound of formula (IV):
• or an optical isomer, diastereomer or enantiomer thereof,
• wherein
• the dashed lines, independently, indicate the presence or absence of a bond;
• A and B are, independently, —(CRaRb)—, wherein each Ra and Rb is, independently, hydrogen or —C1-6 alkyl, and n is 0, 1, 2, 3, or 4;
• R1 is —C(O)ORc, —CONHRd, —C(O)NHOH, —CH2OH, —S(O)2Re, or —C(O)NHS(O)2Rf;
• R2 is hydrogen or —C1-6 alkyl;
• R3, R4, and R5 are, independently, hydrogen or an alcohol protecting group;
• Y is a bond, —O—, —S—, —S(O)—, —S(O)2—, —C(Rg)2—, —CRh═CRi—, —NRj—, or —C═C—;
• Z is hydrogen, cycloalkyl, heterocyclyl, aryl, or heteroaryl;
• Rc is hydrogen, —C1-6 alkyl, —C1-6 heteroalkyl, aryl, heteroaryl, cycloalkyl, and heterocyclyl;
• Rd, Re, and Rf are, independently, —C1-6 alkyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, and heterocyclyl;
• Rg, Rh, and Ri are, independently, hydrogen, —C1-6 alkyl, alkoxy, or hydroxy;
• and
• Rj is hydrogen or —C1-6 alkyl.