Quinolinone lysyl oxidase-like 2 inhibitors and uses thereof

A compound that has the structure of Formula (I), or a pharmaceutically acceptable salt, or solvate thereof:

• wherein,
• each R1 is independently H, D, or F;
• R2 is Br, —CN, —OH, —OC2-C6alkyl, —OC1-C6fluoroalkyl, —SR5, —S(═O)R4, —S(═O)2R4, —S(═O)2N(R5)2, —NR5S(═O)2R4, —C(═O)R4, —OC(═O)R4, —CO2R5, —OCO2R4, —N(R5)2, —OC(═O)N(R5)2, —C(═O)N(R5)2, —NR5C(═O)R4, —NR5C(═O)OR4, C1-C6fluoroalkyl, C1-C6deuteroalkyl, —OC1-C6deuteroalkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C2-C6alkenyl, or substituted or unsubstituted C2-C6alkynyl;
• or R2 is A-L1-;
• L1 is absent, —O—, —NR5—, —S—, —S═O—, —S(═O)2—, C1-C6alkylene, —O(C1-C6alkylene)-, —NR5(C1-C6alkylene)-, —S(C1-C6alkylene)-, —S═O(C1-C6alkylene)-, or —S(═O)2C1-C6alkylene-;
• A is a cyclic ring that is a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted C3-C10cycloalkyl, substituted or unsubstituted C3-C10cycloalkenyl, or substituted or unsubstituted C2-C10heterocycloalkyl, wherein if A is substituted then A is substituted with one or more R6;
• each R6 is independently H, D, halogen, CN, —OR5, —SR5, —S(═O)R4, —S(═O)2R4, —S(═O)2N(R5)2, —NR5S(═O)2R4, —C(═O)R4, —OC(═O)R4, —CO2R5, —OCO2R4, N(R5)2, —OC(═O)N(R5)2, —C(═O)N(R5)2, —NR5C(═O)R4, —NR5C(═O)OR4, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6deuteroalkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C3-C10cycloalkyl, substituted or unsubstituted C3-C10deuterocycloalkyl, substituted or unsubstituted C2-C10heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• each R4 is independently a substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6deuteroalkyl, substituted or unsubstituted C3-C10cycloalkyl, substituted or unsubstituted C3-C10deuterocycloalkyl, substituted or unsubstituted C2-C10heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• each R5 is independently H, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6deuteroalkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C3-C10cycloalkyl, substituted or unsubstituted C3-C10deuterocycloalkyl, substituted or unsubstituted C2-C10heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• or two R5 groups attached to the same N atom are taken together with carbon atom to which they are attached to form a substituted or unsubstituted carbocycle or substituted or unsubstituted heterocycle;
• each R3 is independently H, D, halogen, —CN, —OH, —OC1-C6alkyl, —OC1-C6fluoroalkyl, —OC1-C6deuteroalkyl, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, or C1-C6heteroalkyl;
• m is 0, 1, or 2.