Pharmaceutical composition comprising sacubitril and valsartan
AssigneeSynthon BV
InventorsBohumil Dymacek, Marta Vivancos Martinez, Luis Nogueiras Nieto, Lisardo Alvarez Fernandez, Rohit Kumar, Jose Velada Calzada, Petr Mitas
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Abstract
The present invention relates to a pharmaceutical composition comprising a physical mixture of sacubitril sodium and valsartan disodium, wherein the X-ray powder diffraction pattern of valsartan disodium comprises characteristic peaks at the following 2 theta (±0.2) angles: 4.70°, 9.29°, 22.34°, measured using a Cu Kα radiation. The invention further relates to the use of said pharmaceutical composition as medicament in the treatment of heart failure.
Claims21
A pharmaceutical composition comprising a physical mixture of sacubitril sodium and valsartan disodium, wherein the X-ray powder diffraction pattern of valsartan disodium comprises characteristic peaks at the following 2 theta (±0.2) angles:
- 4.70°, 9.29°, 22.34°, measured using a Cu Kα radiation.
Valsartan disodium having an X-ray powder diffraction pattern comprising characteristic peaks at the following 2 theta ((±0.2) angles:
- 4.70°, 9.29°, 22.34°, measured using a Cu Kα radiation.
Dependencies are inferred from the claim text.