US 10,588,889 B2Granted

Methods of treating hyperalgesia

AssigneeTrevena, Inc.

InventorsConrad Cowan, Michael Koblish, Michael W. Lark

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This application describes compounds and methods that can be used to treat, reverse, or avoid hyperalgesia.

Dependent claims

A method of reversing opioid induced hyperalgesia in a subject in need thereof comprising administering to the subject a compound having a formula of

or a pharmaceutically acceptable salt thereof,
wherein R23, and R24 are each independently null, H, OH, cycle, aryl, branched or unbranched alkyl alcohol, halo, branched or unbranched alkyl, amine, amide, cyano, alkoxy, haloalkyl, alkylsulfonyl, nitrite, alkylsulfanyl;
or R23 and R24 together form an aryl or a cycle that is attached to one or more of the atoms of the thiophene ring.

Dependencies are inferred from the claim text.

A61K 31/35
Having oxygen as the only ring hetero atom, e.g. fungichromin: having six-membered rings with one oxygen as the only ring hetero atom
A61K 31/4433
Containing further heterocyclic ring systems: containing a six-membered ring with oxygen as a ring hetero atom
A61K 31/4436
Containing further heterocyclic ring systems: containing a heterocyclic ring having sulfur as a ring hetero atom
A61K 31/444
Containing further heterocyclic ring systems: containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone

From the US filing history. Foreign family members aren’t listed.

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