Modulators of prostate-specific G-protein receptor (PSGR/OR51E2) and methods of using same
AssigneeDuke University
InventorsTatjana Abaffy, Hiro Matsunami
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Abstract
The present disclosure provides, in part, modulators of prostate-specific G-protein receptor (OR51E2/PSGR) and methods of treating, preventing, and diagnosing prostate cancer using the same.
Claims6
A method of treating prostate cancer or preventing the progression of prostate cancer in a subject in need thereof, comprising:
- administering to the subject a composition consisting of a therapeutically effective amount of one or more OR51E2 ligands and optionally one or more pharmaceutically acceptable carriers, excipients, adjuvants, and diluents, wherein the one or more OR51E2 ligands is 13-cis retinoic acid, or isomers thereof, wherein the one or more ligands binds to OR51E2 on a prostate cancer cell and impedes the progression of the prostate cancer cell, and wherein the prostate cancer cell is a castrate resistant prostate cancer cell.
A method of impeding the progression of a prostate cancer cell, comprising contacting the prostate cancer cell with one or more OR51E2 ligands, wherein the one or more OR51E2 ligands is selected from the group consisting of 13-cis retinoic acid and isomers thereof, and wherein the prostate cancer cell is a castrate resistant prostate cancer cell.
Dependencies are inferred from the claim text.