Pharmaceutical suspensions containing drug particles, devices for their administration, and methods of their use
AssigneeSynAgile Corporation
InventorsAdam Heller, John Spiridigliozzi
Life of this patent
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Abstract
The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.
Claims30
A method of treating a disease comprising administering a pharmaceutical composition comprising one or more drugs into a mouth of a patient via continuous or frequent intermittent administration for a period of at least 4 hours, said method comprising:
- (i) inserting a drug delivery device into the mouth of the patient;
- (ii) administering said pharmaceutical composition into the mouth of said patient via continuous or frequent intermittent administration at a rate between 0.001 mL/hour and 1.25 mL/hour for a period of at least 4 hours;
- and
- (iii) removing said drug delivery device from the mouth of said patient,
- wherein said pharmaceutical composition has a dynamic viscosity greater than 1,000 cP at 37° C. and comprises greater than about 35% (w/w) of said one or more drugs, and wherein a fluctuation index of one of said one or more drugs is less than or equal to 2.0 during said period.
A method of administering a pharmaceutical composition comprising one or more drugs into a mouth of a patient via continuous or frequent intermittent administration for a period of at least 4 hours, said method comprising:
- (i) inserting a drug delivery device into the mouth of the patient;
- (ii) administering said pharmaceutical composition into the mouth of said patient via continuous or frequent intermittent administration at a rate between 0.001 mL/hour and 1.25 mL/hour for a period of at least 4 hours;
- and
- (iii) removing said drug delivery device from the mouth of said patient,
- wherein said pharmaceutical composition has a dynamic viscosity greater than 1,000 cP at 37° C., wherein said drug delivery device comprises a mechanical pump, and wherein a fluctuation index of one of said one or more drugs is less than or equal to 2.0 during said period.
A method of treating a disease comprising administering a pharmaceutical composition comprising one or more drugs into a mouth of a patient via continuous or frequent intermittent administration for a period of at least 4 hours, said method comprising:
- (i) inserting a drug delivery device into the mouth of the patient;
- (ii) administering said pharmaceutical composition into the mouth of said patient via continuous or frequent intermittent administration at a rate between 0.001 mL/hour and 1.25 mL/hour for a period of at least 4 hours;
- and
- (iii) removing said drug delivery device from the mouth of said patient,
- wherein said disease comprises Parkinson's disease, said pharmaceutical composition has a dynamic viscosity greater than 1,000 cP at 37° C., wherein one of said one or more drugs is levodopa, a levodopa prodrug, or a dopamine agonist, and wherein a fluctuation index of one of said one or more drugs is less than or equal to 2.0 during said period.
A method of administering a pharmaceutical composition comprising one or more drugs into a mouth of a patient via continuous or frequent intermittent administration for a period of at least 4 hours, said method comprising:
- (i) inserting a drug delivery device into the mouth of the patient;
- (ii) administering said pharmaceutical composition into the mouth of said patient via continuous or frequent intermittent administration at a rate between 0.001 mL/hour and 1.25 mL/hour for a period of at least 4 hours;
- and
- (iii) removing said drug delivery device from the mouth of said patient,
- wherein said pharmaceutical composition comprises suspended drug particles, and wherein a fluctuation index of one of said one or more drugs is less than or equal to 2.0 during said period.
Dependencies are inferred from the claim text.