Modulating antibacterial immunity via bacterial membrane-coated nanoparticles
AssigneeThe Regents of the University of California
InventorsLiangfang Zhang, Weiwei Gao, Ronnie H. Fang, Che-Ming Jack Hu
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Abstract
Nanoparticles are provided comprising an inner core comprising a non-cellular material, and an outer surface comprising a bacterial membrane, e.g., a bacterial membrane derived from a bacteria outer membrane vesicle. Also provided are compositions, e.g., medicament delivery systems and pharmaceutical compositions, comprising the present nanoparticles. Also provided are uses of the present nanoparticles, pharmaceutical compositions and medicament delivery systems for treating and/or preventing a disease or condition, e.g., bacterial infection, in a subject.
Claims24
A method for treating and/or preventing a disease or condition in a subject, which method comprises administering, to a subject in need of such treatment and/or prevention, an effective amount of a nanoparticle that comprises:
- a) an inner core comprising a non-cellular material;
- and
- b) an outer surface comprising a bacterial membrane,
- wherein said bacterial membrane is a modified or processed bacterial membrane, or said bacterial membrane is derived from a bacteria outer membrane vesicle, or said nanoparticle is configured as a vaccine, and
- wherein said bacterial membrane in the outer surface of said nanoparticle has a protein loading yield, defined as the weight ratio of immobilized proteins to said nanoparticle, of at least from about 1 wt % to about 95 wt % or more.
A method for treating and/or preventing bacterial infection in a subject, which method comprises administering, to a subject in need of such treatment and/or prevention, an effective amount of an immunogenic composition that comprises an effective amount of a nanoparticle comprising:
- a) an inner core comprising a non-cellular material;
- and
- b) an outer surface comprising a bacterial membrane,
- wherein said bacterial membrane is a modified or processed bacterial membrane, or said bacterial membrane is derived from a bacteria outer membrane vesicle, or said nanoparticle is configured as a vaccine, and
- wherein said bacterial membrane in the outer surface of said nanoparticle has a protein loading yield, defined as the weight ratio of immobilized proteins to said nanoparticle, of at least from about 1 wt % to about 95 wt % or more.
Dependencies are inferred from the claim text.