Stable solid lipid particle composition for improved bioavailability of lipophilic compounds for age-related diseases
AssigneeVerdure Sciences, Inc.
InventorsLal Hingorani, Blake Ebersole
Life of this patent
Estimating the term…
Abstract
The present invention provides a delivery system which improves the stability, solubility and permeability of certain types of biologically active compounds in the gut after oral consumption. The delivery system comprises carrier granule comprising an agglomeration of solid lipid particles and a biologically active compound. The biologically active compound may be used with the delivery system to treat illnesses relating to inflammation, oxidation, or protein aggregation where a therapeutic blood and tissue level is required for treating the illness.
Claims22
A delivery system having enhanced oral bioavailability comprising:
- a carrier granule with a particle size from about 150 to about 840 microns,
- wherein the carrier granule comprises an agglomeration of solid lipid particles for oral dosing,
- wherein the solid lipid particles comprise one or more long chain lipid selected from the group consisting of soy lecithin, phosphatidyl choline, stearic acid and ascorbyl palmitate,
- wherein the ratio of stearic acid:phosphatidyl choline is in a range of about 1.25:1 to about 3.5:1,
- wherein the solid lipid particles within the granule have a particle size from about 5 to about 20 microns and wherein the solid lipid particles are encased within the carrier granule, and
- one or more biologically active compounds, wherein the biologically active compound is curcumin or lutein.
Dependencies are inferred from the claim text.