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US 10,588,862 B2Granted
Dexamethasone prodrug compositions and uses thereof
AssigneeRipple Therapeutics Corporation
InventorsIan Charles Parrag, Matthew Alexander John Statham, Kyle Battiston, Dimitra Louka, Hans Christian Fischer, J. Paul Santerre, Wendy Alison Naimark
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Abstract
The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.
Claims50
An article comprising compound 1:
- wherein the article provides controlled release of dexamethasone at 37° C. in 100% bovine serum or at 37° C. in phosphate buffered saline.
An article comprising compound 6:
- wherein the article provides controlled release of dexamethasone at 37° C. in 100% bovine serum or at 37° C. in phosphate buffered saline.
Dependencies are inferred from the claim text.