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US 10,588,859 B2Granted
Topical formulations having enhanced bioavailability
AssigneeBerg LLC
InventorsJohn Patrick McCook, Indushekhar Persaud, Niven Rajin Narain
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Abstract
The present disclosure provides compositions suitable for delivering lipophilic bioactive agents. The compositions may be utilized to treat numerous diseases and conditions that would benefit from the application of a lipophilic bioactive agent.
Claims28
A composition comprising:
- a liposomal concentrate in combination with at least one pharmaceutically acceptable carrier possessing at least one permeation enhancer that comprises ethoxydiglycol;
- wherein the liposomal concentrate comprises:
- a phospholipid selected from the group consisting of lecithin, lysolecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylglycerol, phosphatidic acid, phosphatidylserine, lysophosphatidylcholine, lysophosphatidylethanolamine, lysophosphatidylglycerol, lysophosphatidic acid, lysophosphatidylserine, PEG-phosphatidylethanolamine, PVP-phosphatidylethanolamine, and combinations thereof;
- Coenzyme Q10;
- and
- at least one solubilizer;
- wherein the composition comprises ethoxydiglycol in an amount from about 4% by weight to about 6% by weight of the composition and Coenzyme Q10 in an amount of from about 3% to about 3.3% by weight of the composition.
4 more elements
Dependencies are inferred from the claim text.