Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof

A foam able composition formulated for administration to the skin comprising a carrier composition comprising:

• a) a short chain alcohol comprising ethanol present at a concentration of at least 55% by weight of the carrier;
• b) about 2% to about 50% by weight of the carrier of a protic polar solvent comprising propylene glycol;
• c) a polymeric agent comprising a cellulose ether, wherein the cellulose ether is a hydroxypropyl cellulose present at a concentration of about 0.5% to about 1% by weight of the carrier;
• d) a modulating agent comprising an antioxidizing agent present at a concentration of about 0.1% to about 10% by weight of the carrier;
• e) a metal;
• f) an essential oil;
• and
• g) tetracycline in a therapeutically effective amount of about 1% to about 5% by weight of the carrier,
• wherein the composition is surfactant free, nonaqueous, and tree or essentially free of fatty alcohol.