Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix
AssigneeTherabiome, LLC
InventorsJerome J. Schentag, Mohan Kabadi
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Abstract
The invention provides oral vaccine formulations which deliver an antigen in the vicinity of the distal ileum and the area of the ileal Brake and/or the appendix. These vaccines are useful in the treatment and/or prevention of variety of disorders, including viral and bacterial infections and cancers. Related methods of treatment which use the oral vaccine formulations of the invention are also provided.
Claims18
An oral formulation which delivers a first antigen in the vicinity of the distal ileum and a second antigen in the vicinity of the right colon and/or appendix, the formulation comprising a first capsule and a second capsule, wherein:
- (a) the first capsule comprises
- (i) the second capsule and
- (ii) a first plurality of cores comprising the first antigen,
- wherein a first enteric coating encapsulates the first capsule, and is substantially soluble at a pH between about 7.0 and about 7.6;
- and
- (b) the second capsule comprises a second plurality of cores comprising the second antigen, wherein a second enteric coating encapsulates the second capsule, and is substantially soluble at a pH of less than 6.5;
- wherein the first capsule delivers the second capsule and the first plurality of cores to the distal ileum, and the second capsule delivers the second plurality of cores to the right colon and/or appendix.
Dependencies are inferred from the claim text.