Endoluminal system and method for gastrointestinal treatment

A method, comprising:

• inserting an endoluminal device comprising a flexible tubular member and a chamber into a gastrointestinal tract, wherein the chamber includes first and second flexible elements connected by a bridge member;
• visualizing a portion of the gastrointestinal tract;
• expanding the first and second flexible elements against a wall of the gastrointestinal tract to create a working space within the gastrointestinal tract;
• inserting first and second instruments through the tubular member;
• angling a first tip of the first instrument and a second tip of the second instrument within the chamber toward a lesion within the gastrointestinal tract, wherein the first and second tips are movable independent of each other;
• removing at least a portion of the lesion;
• capturing the removed portion of the lesion within the chamber, wherein the chamber is at least partially enclosed to receive the lesion;
• and
• removing the endoluminal device and captured lesion from the gastrointestinal tract.